Natural GSK-3 inhibitors Tideglucib and gstk3 inhibitors in food

 Tideglusib is a small molecule inhibitor of glycogen synthase kinase 3 (GSK-3) that has shown promise in the treatment of neurodegenerative diseases such as Alzheimer's disease. GSK-3 is an enzyme that is involved in a wide range of cellular processes, including glycogen metabolism, cell cycle regulation, and cell differentiation, and is therefore a potential therapeutic target for a variety of diseases.

As for natural food sources of GSK-3 inhibitors, there are several compounds found in certain foods that have been shown to inhibit GSK-3 activity in vitro or in animal models. These include:

Resveratrol: A compound found in grapes, red wine, and peanuts, resveratrol has been shown to inhibit GSK-3 activity and improve cognitive function in animal models of Alzheimer's disease.

Curcumin: A compound found in turmeric, curcumin has been shown to inhibit GSK-3 activity and reduce the accumulation of amyloid beta, a protein associated with Alzheimer's disease, in animal models.

Berberine: A compound found in several plants, including goldenseal and barberry, berberine has been shown to inhibit GSK-3 activity and improve cognitive function in animal models of Alzheimer's disease.

Epigallocatechin-3-gallate (EGCG): A compound found in green tea, EGCG has been shown to inhibit GSK-3 activity and reduce the accumulation of amyloid beta in animal models of Alzheimer's disease.

While these compounds have shown promise in preclinical studies, their efficacy and safety in humans remains to be fully established. It's important to note that natural food sources of GSK-3 inhibitors should not be considered a replacement for medical treatments, and any use of these compounds should be discussed with a healthcare professional.